For example, photodynamic therapy (PDT) is one of the representative non-invasive remedies that attack malignant cells through ROS-induced cell death mechanisms 3. With a focus on their characteristic reactivity, numerous ROS-related studies have been reported in chemical and biological research for therapeutic and photocatalytic applications 4, 5. –) or hydroxyl radicals, and molecular oxygen-driven non-radical molecules (type II), such as singlet oxygen ( 1O 2) 3.ROS can include chemically reactive radicals (type I), such as superoxide (O 2 Reactive oxygen species (ROS) are one of the most common chemicals in living organisms and industrial fields that respond to normal cellular functioning and catalytic process 1, 2. Overall, the results document an unprecedented polymerization method capable of engineering wavelength, providing a potential basis for designing nanoscale photosensitizers in various ROS-utilizing applications. Furthermore, superior tumor eradication and biocompatibility of the KUP system were confirmed through bioassays. We demonstrate that protonated polymerization exclusively enables photosensitization and closely interacts with oxygen related to the efficiency of photosensitizing. Remarkably, the optimal wavelength for maximum performance can be tuned by modifying the linker, generating ROS despite the absence of metal ions and covalently attached heavy atoms. To address this challenge, we implement a wavelength-engineerable imidazolium-based porous organic photocatalytic ROS generation system (KUP system) via a cost-effective one-pot reaction. However, controlling the wavelength corresponding to operating conditions remains challenging while maintaining high ROS generation. Engineering excitation wavelength of photosensitizers (PSs) for enhanced reactive oxygen species (ROS) generation has inspired new windows for opportunities, enabling investigation of previously impracticable biomedical and photocatalytic applications.
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